Rostad H, Hall K V, Hovig T
J Cardiovasc Surg (Torino). 1984 Jan-Feb;25(1):58-63.
In an attempt to make veins more suitable for bypass grafting, an experimental model in dogs was developed. The saphenous vein on the hind limbs was cannulated with a silastic tube, a ligature was placed proximally and distally, and the tube was left in situ for 1 to 9 weeks. Morphological studies including electron microscopy revealed "arterialization" of the veins with fibromuscular hyperplasia, increased deposition of collagen and preserved vasa vasorum. The endothelium was replaced by irregular cells, probably altered fibroblasts coated by an amorphous material. It is suggested that the "arterialized" veins may become more suitable for bypass grafting. But the luminal surface may be thombogenic and thus the usefulness of the graft may be diminished by thrombosis.
为了使静脉更适合用于搭桥移植，建立了一种犬类实验模型。用硅橡胶管插入后肢的隐静脉，在近端和远端放置结扎线，并将管子留在原位1至9周。包括电子显微镜检查在内的形态学研究显示，静脉出现“动脉化”，伴有纤维肌肉增生、胶原蛋白沉积增加以及血管滋养管保留。内皮被不规则细胞取代，可能是被无定形物质覆盖的改变的成纤维细胞。有人认为，“动脉化”静脉可能更适合用于搭桥移植。但管腔表面可能具有血栓形成性，因此移植的有效性可能会因血栓形成而降低。
