Sandler M P, Kronenberg M W, Forman M B, Wolfe O H, Clanton J A, Partain C L
J Am Coll Cardiol. 1984 May;3(5):1205-11. doi: 10.1016/s0735-1097(84)80178-3.
Alterations in the blood radioactivity affect ventricular volume calculations using count-based radionuclide ventriculography. To study this phenomenon, the effect of time, posture and supine exercise on blood radioactivity, red blood cell count and splenic radioactivity was evaluated. The red blood cell count, and blood, splanchnic and splenic radioactivity remained stable in five patients studied at rest in the supine position. On standing, blood radioactivity increased 10 +/- 3% (standard error of the mean), and abdominal radioactivity decreased 14.5 +/- 6.5% (both p less than 0.05). In 10 patients, splenic radioactivity decreased after supine exercise by 49 +/- 7%, while blood radioactivity increased 10.5 +/- 1.5% and red blood cell count increased 7.5 +/- 1.5% (all p less than 0.001). Splenic radioactivity increased gradually after exercise and decreased after a second exercise period. In the exercising patients, blood radioactivity increased by 14.5% and correlated with an increase in the red blood cell count (r = 0.57, p = 0.01, 19 samples from 10 patients). Reduction in splenic radioactivity also correlated with the increase in red blood cell count (r = -0.51, p = 0.025). The data demonstrate splenic shrinkage in human beings and an inverse relation between changes in splenic and blood radioactivity. These dynamic fluctuations emphasize the need for simultaneous blood sampling for accurate calculation of left ventricular volume and high-light the importance of regional volume shifts during exercise.
血液放射性的改变会影响基于计数的放射性核素心室造影术对心室容积的计算。为研究这一现象，评估了时间、体位和仰卧位运动对血液放射性、红细胞计数及脾脏放射性的影响。在5名仰卧位休息的患者中，红细胞计数、血液、内脏和脾脏放射性保持稳定。站立时，血液放射性增加10±3%（均值标准误差），腹部放射性降低14.5±6.5%（均p<0.05）。在10名患者中，仰卧位运动后脾脏放射性降低49±7%，而血液放射性增加10.5±1.5%，红细胞计数增加7.5±1.5%（均p<0.001）。运动后脾脏放射性逐渐增加，在第二个运动期后降低。在运动的患者中，血液放射性增加14.5%，且与红细胞计数增加相关（r=0.57，p=0.01，来自10名患者的19份样本）。脾脏放射性降低也与红细胞计数增加相关（r=-0.51，p=0.025）。数据表明人类存在脾脏收缩，且脾脏和血液放射性变化呈负相关。这些动态波动强调了为准确计算左心室容积而同时进行血液采样的必要性，并突出了运动期间区域容积变化的重要性。
