Bedikian A Y, Chen T T, Khankhanian N, Heilbrun L K, McBride C M, McMurtrey M J, Bodey G P
J Clin Oncol. 1984 Apr;2(4):305-10. doi: 10.1200/JCO.1984.2.4.305.
This study of 783 patients with histologically confirmed gastric carcinoma has confirmed the importance of several previously recognized patient- and tumor-related characteristics related to prognosis and identified some new ones. Of the tumor-related factors, the ones that showed the strongest relationship to survival following curative gastric resection were tumor stage, histologic type, breach of lymph-node capsule, sinus histiocytosis, and gross appearance. Of the tumor- and patient-related factors, the ones that showed the strongest relationship to survival from time of diagnosis of surgically noncurable disease were status of primary, liver metastasis, serum bilirubin level, ascites, extent of tumor burden, and weight loss. The effect of treatment with 5-fluorouracil (5-FU) on survival duration was at best only minimal. Only those patients who received two or more cycles of 5-FU therapy had survival advantage over the remaining patients. The use of regression analysis has made it possible to make predictions of the prognosis of the patients. These predictions could be used in future studies to determine comparability of prognosis of various groups included in different studies and different arms of a randomized study.
这项对783例经组织学确诊的胃癌患者的研究证实了几个先前已认识到的与预后相关的患者及肿瘤相关特征的重要性，并发现了一些新的特征。在肿瘤相关因素中，与根治性胃切除术后生存关系最密切的是肿瘤分期、组织学类型、淋巴结包膜侵犯、窦组织细胞增生和大体外观。在肿瘤及患者相关因素中，与手术无法治愈疾病诊断时的生存关系最密切的是原发灶状态、肝转移、血清胆红素水平、腹水、肿瘤负荷范围和体重减轻。5-氟尿嘧啶（5-FU）治疗对生存时间的影响充其量只是微乎其微。只有那些接受两个或更多周期5-FU治疗的患者比其余患者有生存优势。回归分析的应用使得对患者预后进行预测成为可能。这些预测可用于未来的研究，以确定不同研究中纳入的各个组以及随机研究的不同组别的预后可比性。
