Perlman S, Szyper M, Kirschbaum J J
J Pharm Sci. 1984 Feb;73(2):259-61. doi: 10.1002/jps.2600730230.
A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for the simultaneous assay of nadolol and bendroflumethiazide in tablet formulations. The tablets were extracted with methanol and, after centrifugation, were chromatographed. A phenyl column was used with a mobile phase of aqueous acetate buffer with sodium chloride-methanol (60:40); detection was at 270 nm. Linearity of both drugs was satisfactory. The procedure can be automated and also applied to bendroflumethiazide formulations and bulk material.
