Lluch S, Conde M V, Diéguez G, López de Pablo A L, González M C, Estrada C, Gómez B
J Pharmacol Exp Ther. 1984 Mar;228(3):749-55.
The effects of vasopressin on the cerebral circulation were studied in conscious goats and in isolated human and goat cerebral arteries. Infusion of 1 to 12 mU of vasopressin into the internal maxillary artery of unanesthetized goats caused dose-dependent reductions in cerebral blood flow, a decrease of 36 +/- 4.7% (mean +/- S.E.) occurring with the highest dose. Cumulative application of vasopressin (10(-12) to 10(-6) M) markedly constricted human and goat cerebral arteries in vitro, the effect being more prominent in human vessels. (1-Deaminopenicillamine, 4-valine)-8-D-arginine-vasopressin, a competitive antagonist of the pressor effects of vasopressin, partially inhibited the cerebral vasoconstriction produced by vasopressin in vivo and in vitro without affecting the vasoconstrictor responses to norepinephrine, 5-hydroxytryptamine and potassium chloride. The results indicate that low concentrations of vasopressin produce constriction of cerebral vessels by direct excitatory effects on specific receptor sites. This effect should be considered in certain pathophysiological states in which vasopressin is released in amounts that could interfere with the proper blood supply to the brain.
在清醒山羊以及分离的人及山羊脑动脉中研究了血管加压素对脑循环的影响。向未麻醉山羊的上颌内动脉输注1至12 mU血管加压素会导致脑血流量呈剂量依赖性减少，最高剂量时减少36±4.7%（平均值±标准误）。在体外，血管加压素（10⁻¹²至10⁻⁶ M）的累积应用可使人和山羊的脑动脉明显收缩，这种作用在人体血管中更为显著。（1-脱氨青霉胺，4-缬氨酸）-8-D-精氨酸血管加压素是血管加压素升压作用的竞争性拮抗剂，它在体内和体外均可部分抑制血管加压素引起的脑血管收缩，而不影响对去甲肾上腺素、5-羟色胺和氯化钾的血管收缩反应。结果表明，低浓度血管加压素通过对特定受体部位的直接兴奋作用使脑血管收缩。在某些病理生理状态下，血管加压素的释放量可能会干扰脑的正常血液供应，此时应考虑到这种作用。
