Björkhem I
J Lipid Res. 1978 Jul;19(5):585-90.
The relative importance of omega-oxidation of fatty acids in livers of starved rats was studied by determination of the ratio between 14C at C1 and at C2, C3, C4 in acetoacetate formed from [16-14C]palmitic acid in vivo and in vitro and from [10(-14)C]decanoic acid in vitro. The results are consistent with the possibility that at least a small fraction of the fatty acids may be subject to primary omega-oxidation prior to beta-oxidation in the ketotic state. The maximal figure for this pathway was calculated to be of the magnitude 5--10%. The metabolic consequences of a pathway involving primary omega-oxidation of fatty acids are discussed.
通过测定在体内和体外由[16-¹⁴C]棕榈酸以及在体外由[10(-¹⁴C)]癸酸生成的乙酰乙酸中C1位与C2、C3、C4位¹⁴C之间的比例，研究了饥饿大鼠肝脏中脂肪酸ω-氧化的相对重要性。结果表明，在酮症状态下，至少有一小部分脂肪酸在β-氧化之前可能先进行初级ω-氧化。该途径的最大占比经计算约为5%-10%。文中讨论了涉及脂肪酸初级ω-氧化途径的代谢后果。
