Mailman D
Life Sci. 1984 Apr 2;34(14):1309-15. doi: 10.1016/0024-3205(84)90001-8.
The possibility of tonic autonomic control over intestinal Na and H2O absorption and whether the cardiovascular system was involved was tested by administration of atropine or guanethidine. 3H2O and 22Na in saline perfused through the lumen were used to calculate unidirectional fluxes and total and absorptive site blood flow in canine ileum. Both atropine and guanethidine had qualitatively similar effects on absorption and blood flow with atropine being quantitatively greater. Net Na and H2O absorption were not increased significantly but their absorptive and secretory unidirectional fluxes were increased significantly. Total blood flow was not affected but absorptive site blood flow was increased and resistance decreased. The absorptive site blood flow was correlated with the absorptive Na fluxes similarly in all groups. The secretory fluxes of Na and H2O were correlated with estimated capillary pressure when all three groups were considered together. It was concluded that there is tonic cholinergic control over intestinal absorption which is mediated, in part, through cardiovascular effects. The findings were consistent with tonic parasympathetic activity having primarily a direct effect on gut absorption and blood flow but tonic sympathetic activity primarily modulating the direct effects of other regulatory mechanisms.
通过给予阿托品或胍乙啶，测试了自主神经对肠道钠和水吸收的紧张性控制的可能性以及心血管系统是否参与其中。用灌注肠腔的生理盐水中的3H2O和22Na来计算犬回肠的单向通量、总血流量和吸收部位血流量。阿托品和胍乙啶对吸收和血流量的影响在性质上相似，但阿托品的影响在数量上更大。钠和水的净吸收没有显著增加，但它们的吸收和分泌单向通量显著增加。总血流量不受影响，但吸收部位血流量增加，阻力降低。在所有组中，吸收部位血流量与钠吸收通量的相关性相似。当将所有三组一起考虑时，钠和水的分泌通量与估计的毛细血管压力相关。得出的结论是，存在对肠道吸收的紧张性胆碱能控制，这部分是通过心血管效应介导的。这些发现与紧张性副交感神经活动主要对肠道吸收和血流量有直接影响，但紧张性交感神经活动主要调节其他调节机制的直接影响一致。
