Aloi J A, Insel T R, Mueller E A, Murphy D L
Life Sci. 1984 Apr 2;34(14):1325-31. doi: 10.1016/0024-3205(84)90003-1.
The effects of m-chlorophenylpiperazine (mCPP), a serotonin receptor agonist, on the release of plasma prolactin (PRL), growth hormone (GH), and cortisol in the rhesus monkey were studied. mCPP was administered intravenously at doses of 0.5, 1.5, and 3.0 mg/kg. GH and cortisol were increased significantly at all doses while PRL was significantly increased only following administration of 3.0 mg/kg mCPP. mCPP administration also produced behavioral alterations in each monkey, including sedation, penile erection, and defecation. PRL, GH and behavioral responses to mCPP were completely blocked by pretreatment with the serotonin antagonist metergoline (MTG). However, pretreatment treatment with MTG failed to entirely anagonize the cortisol response to mCPP. These data suggest that mCPP has prominent neuroendocrine and behavioral effects which are mediated, in part, by serotonergic mechanisms.
研究了5-羟色胺受体激动剂间氯苯哌嗪（mCPP）对恒河猴血浆催乳素（PRL）、生长激素（GH）和皮质醇释放的影响。mCPP以0.5、1.5和3.0mg/kg的剂量静脉给药。所有剂量下GH和皮质醇均显著增加，而仅在给予3.0mg/kg mCPP后PRL才显著增加。给予mCPP还使每只猴子出现行为改变，包括镇静、阴茎勃起和排便。用5-羟色胺拮抗剂美替拉酮（MTG）预处理可完全阻断mCPP引起的PRL、GH和行为反应。然而，MTG预处理未能完全拮抗mCPP引起的皮质醇反应。这些数据表明，mCPP具有显著的神经内分泌和行为效应，部分由5-羟色胺能机制介导。
