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骨骼肌组分对神经突发育的神经营养作用。

Neuronotrophic effects of skeletal muscle fractions on neurite development.

作者信息

Hsu L, Natyzak D, Trupin G L

出版信息

Muscle Nerve. 1984 Mar-Apr;7(3):211-7. doi: 10.1002/mus.880070305.

DOI:10.1002/mus.880070305
PMID:6708967
Abstract

Soluble fractions of chick embryonic skeletal muscle stimulated radial outgrowth of long neurites from peripheral ganglia. Dorsal root ganglia were more responsive to the growth stimulus of muscle fractions than sympathetic ganglia. Muscle fractions from chicks immobilized with d-tubocurarine chloride (dtc) were significantly more effective in stimulating growth than normal muscle fractions. Neuritic outgrowth stimulated by muscle fractions was not blocked by antisera to the Nerve Growth Factor (NGF) indicating that these neuronotrophic effects were not due to NGF.

摘要

鸡胚骨骼肌的可溶性组分刺激外周神经节长出长神经突。背根神经节比交感神经节对肌肉组分的生长刺激反应更敏感。用氯化筒箭毒碱(dtc)固定的鸡的肌肉组分在刺激生长方面比正常肌肉组分显著更有效。肌肉组分刺激的神经突生长不受抗神经生长因子(NGF)抗血清的阻断,这表明这些神经营养作用不是由NGF引起的。

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