McPherson D, Blanks J, Foltz E
Neurosurgery. 1984 Feb;14(2):161-6. doi: 10.1227/00006123-198402000-00007.
Acute elevated intracranial pressure (ICP) effects on the auditory evoked response (AER) were studied in the rabbit. Simultaneous CSF infusions to increase ICP and contralateral ICP pressure recordings were done through bilateral ventriculostomies. During rarefaction auditory stimulation, a minicomputer obtained a time-locked AER from ongoing electroencephalographic activity at base line ICP mean pressure and at three levels of increased ICP (250, 500, and 700 mm CSF) above base line. The results showed a statistically significant increased latency of the N3-P3 portion of the AER as well as of the P1-P3 central conduction time. The amplitude of AERs appeared unchanged. The effect is reversible and presumably is a neuropraxic type pressure effect on brain stem auditory pathways. Its clinical relevance is discussed.
在兔子身上研究了急性颅内压（ICP）升高对听觉诱发电位（AER）的影响。通过双侧脑室造瘘术同时进行脑脊液输注以升高ICP，并记录对侧ICP压力。在稀疏听觉刺激期间，一台小型计算机在基线ICP平均压力以及高于基线的三个ICP升高水平（250、500和700 mm脑脊液）下，从正在进行的脑电图活动中获取与时间锁定的AER。结果显示，AER的N3 - P3部分以及P1 - P3中央传导时间在统计学上有显著增加的潜伏期。AER的幅度似乎没有变化。这种影响是可逆的，推测是对脑干听觉通路的一种神经失用型压力效应。文中讨论了其临床相关性。
