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盲法对新生期用丙酸睾酮处理的雄性大鼠生殖器官生长的影响。

Effect of blinding on the growth of reproductive organs in male rats treated neonatally with testosterone propionate.

作者信息

Vanĕcek J, Illnerová H

出版信息

Physiol Bohemoslov. 1984;33(1):75-80.

PMID:6709729
Abstract

Prepubertal blinding slightly retards the growth of seminal vesicles and prostate in male Wistar rats. Neonatal administration of testosterone propionate (TP) increases the susceptibility of rats to light deprivation. The growth of testes, seminal vesicles and prostate is markedly retarded in TP-treated rats blinded at 30 days of age. However, prepubertal blinding does not inhibit the tissue growth completely since even in TP-treated animals steady growth of reproductive organs occurs. Blinding of TP-treated adult rats induces involution of seminal vesicles and prostate although it has no effect on testis weight. The weight of testes can thus be influenced by light deprivation only during its growth in maturing animals, whereas the weights of seminal vesicles and prostate may be affected even in adult animals.

摘要

青春期前致盲会轻微延缓雄性Wistar大鼠精囊和前列腺的生长。新生期给予丙酸睾酮(TP)会增加大鼠对光剥夺的易感性。在30日龄致盲的TP处理大鼠中,睾丸、精囊和前列腺的生长明显受到抑制。然而,青春期前致盲并不会完全抑制组织生长,因为即使在TP处理的动物中,生殖器官也会持续生长。TP处理的成年大鼠致盲会导致精囊和前列腺退化,尽管对睾丸重量没有影响。因此,睾丸重量仅在成熟动物生长期间会受到光剥夺的影响,而精囊和前列腺的重量即使在成年动物中也可能受到影响。

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