Malmary M F, Labat C, Casanovas A M, Oustrin J
Res Commun Chem Pathol Pharmacol. 1984 Feb;43(2):335-8.
Changes in mouse brain homogenates oxygen uptake are determined, following intraperitoneal injection of misonidazole (100 or 500 mg/kg), at one of four circadian stages. An analysis of periodic regressions of the observed data shows that the circadian variability of brain oxygen utilization is affected by the timing of drug administration.
在四个昼夜节律阶段之一，腹腔注射米索硝唑（100或500毫克/千克）后，测定小鼠脑匀浆的氧摄取变化。对观测数据的周期性回归分析表明，脑氧利用的昼夜节律变异性受给药时间的影响。
