急性心肌梗死中的乳酸脱氢酶同工酶LD1及几个比值

LD1 and several ratios of lactate dehydrogenase isoenzymes in acute myocardial infarction.

作者信息

Chung S J

出版信息

South Med J. 1984 Apr;77(4):436-41. doi: 10.1097/00007611-198404000-00007.

DOI:10.1097/00007611-198404000-00007

Abstract

The sensitivity and specificity of three parameters--ECG, creatine kinase MB isoenzyme and LD isoenzymes--were compared in 385 consecutive patients hospitalized for clinically suspected acute myocardial infarction (MI). In 147 patients acute MI was diagnosed on the basis of three parameters. In the remaining 238 patients acute MI was ruled out. Decision values for LD1, LD1/total LD, LD1/(LD2 + LD3 + LD4 + LD5), and the sum of LD1/LD2 + LD1/total LD + LD1/LD2 + LD3 + LD4 + LD5) were selected as 70 U/L, 0.33, 0.5, and 1.79, respectively for the test positivity of LD isoenzymes for acute MI. These new criteria, with the decision values, are proposed as test positivity of CK-MB and LD isoenzymes for acute myocardial infarction.

摘要

对385例因临床疑似急性心肌梗死（MI）而住院的连续患者，比较了三项指标——心电图、肌酸激酶MB同工酶和乳酸脱氢酶同工酶——的敏感性和特异性。147例患者根据这三项指标诊断为急性心肌梗死。其余238例患者排除急性心肌梗死。对于急性心肌梗死乳酸脱氢酶同工酶检测阳性，将LD1、LD1/总LD、LD1/（LD2 + LD3 + LD4 + LD5）以及LD1/LD2 + LD1/总LD + LD1/（LD2 + LD3 + LD4 + LD5）之和的判定值分别选定为70 U/L、0.33、0.5和1.79。这些带有判定值的新标准被提议作为急性心肌梗死肌酸激酶MB和乳酸脱氢酶同工酶检测阳性的标准。