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The catechol estrogen, 2-hydroxyestradiol, inhibits catechol-O-methyltransferase activity in neuroblastoma cells.

作者信息

Lloyd T, Weisz J, Breakefield X O

出版信息

J Neurochem. 1978 Jul;31(1):245-50. doi: 10.1111/j.1471-4159.1978.tb12455.x.

DOI:10.1111/j.1471-4159.1978.tb12455.x
PMID:671023
Abstract
摘要

相似文献

1
The catechol estrogen, 2-hydroxyestradiol, inhibits catechol-O-methyltransferase activity in neuroblastoma cells.儿茶酚雌激素2-羟雌二醇可抑制神经母细胞瘤细胞中的儿茶酚-O-甲基转移酶活性。
J Neurochem. 1978 Jul;31(1):245-50. doi: 10.1111/j.1471-4159.1978.tb12455.x.
2
Inhibition of the catechol-O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by catecholamine: implications for the mechanism of estrogen-induced carcinogenesis.儿茶酚胺对儿茶酚-O-甲基转移酶催化的2-和4-羟基雌二醇O-甲基化的抑制作用:对雌激素诱导致癌机制的影响。
Arch Biochem Biophys. 1993 Jul;304(1):248-56. doi: 10.1006/abbi.1993.1346.
3
A comparison of 2-hydroxyestradiol and U-0521 (3'4'-dihydroxy-2-methylpropiophenone, Upjohn) as in situ and in vitro inhibitors of tyrosine hydroxylase.
J Neurochem. 1982 Apr;38(4):948-54. doi: 10.1111/j.1471-4159.1982.tb05334.x.
4
Catecholamines block the antimitogenic effect of estradiol on human glomerular mesangial cells.儿茶酚胺可阻断雌二醇对人肾小球系膜细胞的抗有丝分裂作用。
Hypertension. 2003 Sep;42(3):349-55. doi: 10.1161/01.HYP.0000088320.81260.26. Epub 2003 Aug 11.
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Role of methoxyestradiols in the growth inhibitory effects of estradiol on human glomerular mesangial cells.甲氧基雌二醇在雌二醇对人肾小球系膜细胞生长抑制作用中的作用。
Hypertension. 2002 Feb;39(2 Pt 2):418-24. doi: 10.1161/hy0202.103297.
6
Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis.2-氟雌二醇和4-氟雌二醇的微粒体羟基化生成儿茶酚代谢物及其转化为甲醚:儿茶酚雌激素作为激素致癌作用的可能介质。
Mol Pharmacol. 1993 Apr;43(4):534-41.
7
2-Methoxyestradiol, an endogenous 17β-estradiol metabolite, inhibits microglial proliferation and activation via an estrogen receptor-independent mechanism.2-甲氧基雌二醇,一种内源性17β-雌二醇代谢物,通过一种不依赖雌激素受体的机制抑制小胶质细胞的增殖和活化。
Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E313-22. doi: 10.1152/ajpendo.00418.2015. Epub 2016 Jan 5.
8
Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta.雌二醇-17β及其细胞色素 P450 和儿茶酚-O-甲基转移酶衍生代谢物刺激子宫动脉内皮细胞增殖:雌激素受体-α与雌激素受体-β的作用。
Hypertension. 2010 Apr;55(4):1005-11. doi: 10.1161/HYPERTENSIONAHA.109.146399. Epub 2010 Mar 8.
9
Metabolism of [3H]2-hydroxyestradiol by cultured porcine granulosa cells: evidence for the presence of a catechol-O-methyltransferase pathway and a direct stimulatory effect of 2-methoxyestradiol on progesterone production.
Biol Reprod. 1987 Apr;36(3):562-71. doi: 10.1095/biolreprod36.3.562.
10
The catechol estrogen, 2-hydroxyestradiol-17 alpha, is formed from estradiol-17 alpha by hypothalamic tissue in vitro and inhibits tyrosine hydroxylase.儿茶酚雌激素,即2-羟雌二醇-17α,在体外由下丘脑组织从雌二醇-17α生成,并抑制酪氨酸羟化酶。
Endocrinology. 1982 Nov;111(5):1734-6. doi: 10.1210/endo-111-5-1734.

引用本文的文献

1
Catechol-O-methyltransferase in the brain of the male African catfish,Clarias gariepinus; distribution and significance for the metabolism of catecholestrogens and dopamine.脑内儿茶酚-O-甲基转移酶在雄性非洲鲶鱼(Clarias gariepinus)中的分布及其对儿茶酚雌激素和多巴胺代谢的意义。
Fish Physiol Biochem. 1989 Jun;7(1-6):201-10. doi: 10.1007/BF00004708.
2
Catecholestrogens inhibit dopamine methylation in the gonadotrops of the African catfish,Clarias gariepinus.儿茶酚雌激素抑制非洲鲶性腺促激素细胞中的多巴胺甲基化。
Fish Physiol Biochem. 1989 Jul;6(4):207-12. doi: 10.1007/BF01875023.
3
Reduction of menopausal hot flushes by methyldopa. A double blind crossover trial.
Eur J Clin Pharmacol. 1981;20(6):413-6. doi: 10.1007/BF00542092.