Chaturvedi A K, Rao N G
Toxicology. 1984 Mar;30(2):149-55. doi: 10.1016/0300-483x(84)90125-2.
The influence of phencyclidine (PCP) on the tissue distribution of pentobarbital in male Swiss mice (20-25 g) was investigated. Animals pretreated with PCP (179 mumol/kg/day) for 4 days, i.p., were administered pentobarbital (60 mg/kg, i.p.) 24 h after the PCP injection, sacrificed at various time intervals, and tissues (serum, brain, liver and kidney) were collected. Pentobarbital levels in tissues were determined by the gas liquid chromatography. When compared to the control group, PCP treatment decreased the pentobarbital level by 68% in liver and increased the level by 97% in kidney at 45 min post-injection. No significant change in serum and brain pentobarbital level was noted with either group. These data indicate that PCP influences the translocation of pentobarbital.
研究了苯环己哌啶（PCP）对雄性瑞士小鼠（20 - 25克）中戊巴比妥组织分布的影响。经腹腔注射PCP（179微摩尔/千克/天）预处理4天的动物，在注射PCP后24小时经腹腔注射戊巴比妥（60毫克/千克），在不同时间间隔处牺牲动物，并收集组织（血清、脑、肝和肾）。通过气相色谱法测定组织中的戊巴比妥水平。与对照组相比，PCP处理使注射后45分钟时肝脏中的戊巴比妥水平降低了68%，并使肾脏中的水平升高了97%。两组血清和脑中的戊巴比妥水平均未观察到显著变化。这些数据表明PCP影响戊巴比妥的转运。
