Nair C R, Stith I E, Nair R R, Das S K
J Nutr. 1978 Aug;108(8):1234-43. doi: 10.1093/jn/108.8.1234.
The effects of parenteral administration of aminoethyl phosphonic acid (AEP) on the liver microsomal drug metabolism and ultrastructure were studied in normal and 1% cholesterol-fed albino rats. AEP administration to rats fed a stock-diet resulted in decreased demethylation of aminopyrine with a concomitant fall in cytochrome P-450 level. Aniline hydroxylation remained unaltered. AEP injection to cholesterol-fed rats, caused marked reduction in both aminopyrine demethylation and aniline hydroxylation, with a significant increase in cytochrome P-450 level. AEP injection to both control and cholesterol-fed animals produced a modest increase in Bilirubin UDP-glucuronyl transferase. RNA:DNA ratio showed remarkable elevation in rats fed the cholesterol diet with AEP injection. AEP injection caused an atypical smooth endoplasmic reticulum and a marked loss of nuclear euchromatin. Effect of AEP was more pronounced in rats receiving the cholesterol-diet. AEP administration thus induces structural and drug metabolic enzyme alteration in liver.
在正常和喂食1%胆固醇的白化大鼠中，研究了肠胃外给予氨基乙基膦酸（AEP）对肝脏微粒体药物代谢和超微结构的影响。给喂食普通饲料的大鼠给予AEP，导致氨基比林去甲基化减少，同时细胞色素P-450水平下降。苯胺羟化作用保持不变。给喂食胆固醇的大鼠注射AEP，导致氨基比林去甲基化和苯胺羟化作用均显著降低，同时细胞色素P-450水平显著升高。给对照动物和喂食胆固醇的动物注射AEP，均使胆红素UDP-葡萄糖醛酸基转移酶适度增加。在注射AEP的喂食胆固醇饮食的大鼠中，RNA:DNA比值显著升高。注射AEP导致非典型的滑面内质网和核常染色质明显丢失。AEP的作用在接受胆固醇饮食的大鼠中更为明显。因此，给予AEP可诱导肝脏结构和药物代谢酶的改变。
