烟酸对大鼠脑内儿茶酚胺合成的影响。

Effect of nicotinic acid on catecholamine synthesis in rat brain.

作者信息

Nakashima Y, Sanada H, Utsuki Y, Kawada S

出版信息

J Nutr Sci Vitaminol (Tokyo). 1978;24(2):67-76. doi: 10.3177/jnsv.24.67.

DOI:10.3177/jnsv.24.67

Abstract

Effect of nicotinic acid on the formation of catecholamine has been studied. Norepinephrine and dopamine concentrations in brain were 30 per cent higher and brain catecholamine formation was 50 per cent higher in the nicotinic acid-supplemented rats than the nicotinic acid-deficient rats. However, these catecholamine levels of the nicotinic acid-deficient rats were recovered by the administration of nicotinic acid. The concentration of brain tyrosine was unaltered after administration of nicotinic acid to the nicotinic acid-deficient rats. Therefore, the changes catecholamine formation by the nicotinic acid supplementation were not due to the difference of tyrosine concentration in the brain which is the precursor for catecholamine biosynthesis. As the difference of catecholamine concentration between the nicotinic acid deficient and the nicotinic acid supplemented group was smaller than that of catecholamine formation of these groups, the turnover of catecholamine was supposed to be decreased in nicotinic acid deficiency.

摘要

已对烟酸对儿茶酚胺形成的影响进行了研究。与缺乏烟酸的大鼠相比，补充烟酸的大鼠大脑中的去甲肾上腺素和多巴胺浓度高30%，大脑儿茶酚胺形成量高50%。然而，通过给予烟酸可使缺乏烟酸的大鼠的这些儿茶酚胺水平恢复。对缺乏烟酸的大鼠给予烟酸后，大脑酪氨酸浓度未改变。因此，补充烟酸引起的儿茶酚胺形成变化并非由于大脑中酪氨酸浓度的差异，而酪氨酸是儿茶酚胺生物合成的前体。由于缺乏烟酸组与补充烟酸组之间儿茶酚胺浓度的差异小于这些组儿茶酚胺形成的差异，因此推测在缺乏烟酸的情况下儿茶酚胺的周转会减少。