Lindahl S G, Hulse M G, Hatch D J
Acta Anaesthesiol Scand. 1984 Feb;28(1):52-6. doi: 10.1111/j.1399-6576.1984.tb02010.x.
In 58 infants and children with body weights between 2.8 and 20.5 kg carbon dioxide production (VCO2 ml min-1) was measured during halothane anaesthesia for minor surgical procedures. In 22 cases measurements were made during both spontaneous and controlled ventilation during the same operation. A non-rebreathing circuit was used. Expired ventilation volume was measured with a dry gas meter and expired gas collected during 3-5 min in a Douglas bag. The carbon dioxide fraction of exhaled gas was determined with a sampling Gould capnograph. A respiratory quotient (RQ) of 0.8 was used to calculate oxygen consumption (VO2 ml min-1). During spontaneous breathing, regression analysis of the relationship between VCO2 and kg and between VO2 and kg showed high intercepts while corresponding relations to kg3/4 revealed an almost direct proportionality. Thus, VCO2 and VO2 ought to be related to body weight in kg3/4 in spontaneously breathing children. The mean value (+/- 1 s.d.) for VCO2 was 11.4 +/- 3.1 ml kg-3/4 and for VO2 14.2 +/- 3.9 ml kg-3/4. During controlled ventilation, the relationship between kg b.w. showed for VCO2 as well as for VO2 an almost direct proportionality with a mean value (+/- 1 s.d.) for VCO2 of 6.3 +/- 1.6 ml min-1 kg-1 and for VO2 of 7.8 +/- 2.0 ml min-1 kg-1. Prediction of VO2 for infants and children of this size could be based upon 14 X kg3/4 during halothane anaesthesia and surgery.
对58名体重在2.8至20.5千克之间的婴幼儿，在进行小型外科手术的氟烷麻醉期间测量了二氧化碳生成量（VCO2，毫升/分钟）。在22例手术中，于同一手术过程中的自主呼吸和控制通气期间均进行了测量。使用了无重复呼吸回路。用干式气体流量计测量呼出通气量，并在3至5分钟内将呼出气体收集在道格拉斯袋中。用采样型古尔德二氧化碳监测仪测定呼出气体中的二氧化碳含量。使用呼吸商（RQ）0.8来计算耗氧量（VO2，毫升/分钟）。在自主呼吸期间，对VCO2与体重以及VO2与体重之间关系的回归分析显示截距较高，而与体重的3/4次方的相应关系则显示几乎呈正比。因此，在自主呼吸的儿童中，VCO2和VO2应与体重的3/4次方相关。VCO2的平均值（±1标准差）为11.4±3.1毫升·千克-3/4，VO2为14.2±3.9毫升·千克-3/4。在控制通气期间，体重与VCO2以及VO2之间的关系几乎呈正比，VCO2的平均值（±1标准差）为6.3±1.6毫升/分钟·千克-1，VO2为7.8±2.0毫升/分钟·千克-1。对于这个年龄段的婴幼儿，在氟烷麻醉和手术期间，VO2的预测可基于14×体重的3/4次方。
