Hemodynamic effects of diuretic therapy in hypertension.

The antihypertensive effect of diuretics is well documented. At least some preserved kidney function seems to be necessary to achieve a demonstrable effect. The importance of fluid volume reduction for the antihypertensive effect of these drugs during long-term treatment is however uncertain. The effects on central hemodynamics vary according to the literature, but the blood pressure reduction in responders (delta MAP greater than 10%) may primarily be explained by a reduction of the total peripheral vascular resistance. The peripheral circulation is influenced in the same way. Sometimes a flow reduction is observed, and sometimes a resistance reduction. In spite of a lasting blood pressure reduction after treatment with diuretics, the structural hypertensive vascular changes do not seem to be influenced.