Ernstoff M S, Kirkwood J M
Am J Med. 1984 Apr;76(4):593-6. doi: 10.1016/0002-9343(84)90282-1.
Bone marrow aspirates and biopsy specimens in 12 patients with solid tumors treated with recombinant interferon alpha-2, 3 to 100 X 10(6) units per day, were evaluated in a blinded fashion both before and after therapy. No change in overall cellularity was noted. There was significant accumulation of lymphocytes (3.9 +/- 1 versus 10 +/- 2.7, p = 0.036), decrease in eosinophils (4.5 +/- 0.8 versus 2.2 +/- 0.7, p = 0.011), and decrease in red cell precursors (36.4 +/- 3.1 versus 28 +/- 4.2, p = 0.091). A trend to accumulation of white cell precursors, metamyelocytes (8.8 +/- 1.4 versus 12 +/- 2.0, p = NS), and band forms (10.0 +/- 1 versus 12.1 +/- 1.2, p = NS) was noted. No megaloblastosis, ring sideroblasts, or block in differentiation was observed. These observations are most consistent with reversible block in release of cells from the bone marrow.
对12例接受重组干扰素α-2治疗的实体瘤患者的骨髓穿刺物和活检标本进行了评估，治疗剂量为每天3至100×10⁶单位。在治疗前后以盲法进行评估。未观察到总体细胞数量的变化。淋巴细胞显著积聚（3.9±1对10±2.7，p = 0.036），嗜酸性粒细胞减少（4.5±0.8对2.2±0.7，p = 0.011），红细胞前体减少（36.4±3.1对28±4.2，p = 0.091）。观察到白细胞前体、晚幼粒细胞（8.8±1.4对12±2.0，p =无统计学意义）和杆状核细胞（10.0±1对12.1±1.2，p =无统计学意义）有积聚趋势。未观察到巨幼细胞贫血、环形铁粒幼细胞或分化阻滞。这些观察结果最符合骨髓细胞释放的可逆性阻滞。
