Dutcher J P
Am J Med Sci. 1984 Mar-Apr;287(2):11-7. doi: 10.1097/00000441-198403000-00003.
Granulocyte transfusion therapy has been used as an adjunct to broad spectrum antibiotics in the management of serious infections in granulocytopenic patients. This treatment is based upon the observation that the incidence of infection is inversely related to the absolute granulocyte count in granulocytopenic patients and upon the demonstrated value of replacement therapy of other blood cell components such as platelets for thrombocytopenia. In addition, the occurrence of dramatic clinical improvement frequently noted with only small increases in granulocyte count as the marrow begins to regenerate suggests that transfusions of granulocytes should be of benefit.
粒细胞输注疗法已被用作广谱抗生素的辅助手段，用于治疗粒细胞减少患者的严重感染。这种治疗方法基于以下观察结果：粒细胞减少患者的感染发生率与绝对粒细胞计数呈负相关，以及其他血细胞成分（如血小板用于治疗血小板减少症）替代疗法已证实的价值。此外，随着骨髓开始再生，粒细胞计数仅略有增加时就经常出现显著的临床改善，这表明输注粒细胞应该是有益的。
