Weenink G H, Treffers P E, Vijn P, Smorenberg-Schoorl M E, Ten Cate J W
Am J Obstet Gynecol. 1984 Apr 15;148(8):1092-7. doi: 10.1016/0002-9378(84)90634-3.
In 57 patients with pregnancy-induced or aggravated hypertension, antithrombin III levels correlated inversely with maternal morbidity. Morbidity was determined by the maximal diastolic blood pressure, disturbance of renal and liver function, and thrombocytopenia. Antithrombin III levels and platelet counts correlated inversely with the degree of placental infarction. Proteinuria (grams per 24 hours) was most predictive of fetal outcome, which was considered to be either favorable if a healthy baby could be discharged with its mother or unfavorable in case of perinatal death or a prolonged stay in the neonatal intensive care unit. Plasma antithrombin III and serum glutamic oxaloacetic transaminase levels, in that order, augmented the number of correct predictions. Antithrombin III inhibits blood coagulation by forming irreversible complexes with activated clotting enzymes, notably with factor Xa and thrombin. Evidence is presented which suggests that antithrombin III levels in preeclampsia are depressed as a result of increased consumption in the maternal vascular tree, rather than decreased synthesis or increased urinary loss.
在57例妊娠高血压综合征或妊娠合并高血压患者中，抗凝血酶III水平与孕产妇发病率呈负相关。发病率由最高舒张压、肾和肝功能紊乱以及血小板减少症决定。抗凝血酶III水平和血小板计数与胎盘梗死程度呈负相关。蛋白尿（每24小时克数）最能预测胎儿结局，如果健康婴儿能与其母亲一同出院，则认为结局良好；如果发生围产期死亡或在新生儿重症监护病房长期住院，则认为结局不良。血浆抗凝血酶III和血清谷草转氨酶水平依次增加了正确预测的数量。抗凝血酶III通过与活化的凝血酶形成不可逆复合物来抑制血液凝固，特别是与Xa因子和凝血酶。有证据表明，子痫前期患者抗凝血酶III水平降低是由于母体血管系统中消耗增加，而非合成减少或尿中丢失增加所致。
