Roberts E D, Baskin G B, Soike K, Gibson S V
Am J Vet Res. 1984 Mar;45(3):523-30.
Gross and microscopic lesions of experimental simian varicella (Delta herpesvirus) infection in African green monkeys (Cercopithecus aethiops) are described. In stratified squamous epithelium, such as the epidermis, tongue, and esophagus, focal areas of epidermal hyperplasia, ballooning degeneration, and blood-filled vesicle formation with ulceration were apparent. Most visceral organs were involved, and the changes included necrosis, hemorrhage, and characteristic intranuclear eosinophilic inclusions in a variety of cells. A generalized vascular involvement was present with intranuclear inclusions in the endothelial and smooth muscle cells in various organs. The nervous system was normal on gross and microscopic examination. Virus titer and serum transferase values were correlated with the clinical signs of infection.
描述了非洲绿猴（猕猴属埃塞俄比亚种）实验性猴水痘（δ疱疹病毒）感染的大体和微观病变。在复层鳞状上皮，如表皮、舌和食管中，可见表皮增生、气球样变性、充满血液的水疱形成并伴有溃疡的局灶性区域。大多数内脏器官受累，变化包括坏死、出血以及各种细胞中特征性的核内嗜酸性包涵体。存在全身性血管受累，各器官的内皮细胞和平滑肌细胞中有核内包涵体。大体和显微镜检查显示神经系统正常。病毒滴度和血清转氨酶值与感染的临床症状相关。
