Meyerhoff W L, Giebink G S, Shea D A
Ann Otol Rhinol Laryngol. 1984 Mar-Apr;93(2 Pt 1):136-9. doi: 10.1177/000348948409300207.
Recent clinical and laboratory observations suggest that otitis media can occur in the absence of visible tympanic membrane changes (silent otitis media). Temporal bone histopathology was studied in 38 chinchillas that had been subjected to conditions known to predispose these animals to otitis media. Morphological changes were compared to a control group of 25 nonmanipulated animals. The tympanic membranes were examined at intervals and during the immediate premortem period with the operating microscope. Thirty-one tympanic membranes in the experimental group and all tympanic membranes in the control group were judged to be normal (gray and translucent) throughout the study period. The middle ears from the experimental group histologically manifested varying amounts of effusion, mucosal edema, granulation tissue, hyperemia of the subepithelial space, hemorrhage in the middle ear space, and abundant polymorphonuclear leukocytes in the middle ear cleft. These findings were not present in the control group.
近期的临床和实验室观察表明，中耳炎可在鼓膜无明显变化的情况下发生（隐匿性中耳炎）。对38只龙猫的颞骨组织病理学进行了研究，这些龙猫曾处于已知会使其易患中耳炎的条件下。将形态学变化与25只未做处理的动物组成的对照组进行比较。在实验期间，定期使用手术显微镜检查鼓膜，并在濒死期即刻进行检查。在整个研究期间，实验组的31只鼓膜和对照组的所有鼓膜均被判定为正常（灰白色且半透明）。实验组的中耳在组织学上表现出不同程度的积液、黏膜水肿、肉芽组织、上皮下间隙充血、中耳腔出血以及中耳裂内大量多形核白细胞。对照组未出现这些发现。
