Smith G P, Rudge P J, Peters T J
Ann Neurol. 1984 Jan;15(1):104-7. doi: 10.1002/ana.410150120.
A number of recent studies report response of patients with carpal tunnel syndrome to pyridoxine treatment. Neurological and biochemical studies were therefore performed on six patients both before and after treatment with pyridoxine for at least 9 weeks. Free pyridoxal, pyridoxal phosphate, and total pyridoxal were assayed in plasma and neutrophils. The pyridoxal status was also estimated by assaying red cell aspartate aminotransferase. No evidence was obtained to suggest that these patients were deficient in either pyridoxal or pyridoxal phosphate. Although four of the patients claimed some partial symptomatic relief, there was no consistent improvement in clinical findings or neurophysiological measurements following pyridoxine treatment.
近期的多项研究报告了腕管综合征患者对吡哆醇治疗的反应。因此，对6例患者在接受至少9周吡哆醇治疗前后进行了神经学和生物化学研究。测定了血浆和中性粒细胞中的游离吡哆醛、磷酸吡哆醛和总吡哆醛。还通过测定红细胞天冬氨酸转氨酶来评估吡哆醛状态。没有证据表明这些患者存在吡哆醛或磷酸吡哆醛缺乏。尽管有四名患者称症状有部分缓解，但吡哆醇治疗后临床症状或神经生理学测量结果并无持续改善。
