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Stimulation of rat liver 4-hydroxybenzoate: polyprenyl transferase activity by a cytosolic protein factor; evidence for a polyprenyl pyrophosphate transport protein.

作者信息

Gupta A, Paton B C, Ranganathan S, Rudney H

出版信息

Biochem Biophys Res Commun. 1984 Mar 30;119(3):1109-15. doi: 10.1016/0006-291x(84)90889-1.

DOI:10.1016/0006-291x(84)90889-1
PMID:6712669
Abstract

Rat liver postmicrosomal supernatant contains a factor which stimulates the 4-hydroxybenzoate:polyprenyl transferase activity of whole mitochondria and inner mitochondrial membrane fragments. The factor involved appears to be a heat stable, nondializable protein sensitive to tryptic hydrolysis and has been partially purified. Since this protein binds nonaprenyl pyrophosphate and stimulates its transport into mitochondria but shows no similar effect with 4-hydroxybenzoate, it is suggested that this protein also acts as an all trans polyprenyl pyrophosphate carrier protein.

摘要

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