Chiarantini E
Boll Soc Ital Biol Sper. 1984 Mar 30;60(3):523-7.
Taurocholic uptake in ethinyl estradiol cholestatic rats is significantly lower than in untreated rats. In the days following treatment withdrawal there is only a slow increase in uptake, which is still statistically lower than normal at the 11th day. Taurocholic acid uptake behaves in a different way from biliary flow and the amount of excreted bile acids. The diversity could be attributed to a different behaviour of bile acid carriers at the sinusoidal and biliary membranes in the hepatocyte or to a normalisation of bile acid carriers and Na+,K+,-ATPase activity at different times.
乙炔雌二醇诱导的胆汁淤积大鼠中牛磺胆酸的摄取显著低于未处理的大鼠。在撤药后的几天里，摄取量仅缓慢增加，在第11天时仍显著低于正常水平。牛磺胆酸的摄取与胆汁流量和胆汁酸排泄量的变化方式不同。这种差异可能归因于肝细胞中窦状隙膜和胆小管膜上胆汁酸载体的不同行为，或者是由于胆汁酸载体和Na +，K + -ATP酶活性在不同时间的正常化。
