Harris A L, Swamy V C, Triggle D J
Can J Physiol Pharmacol. 1984 Jan;62(1):146-50. doi: 10.1139/y84-024.
Reactivities of portal veins from spontaneously hypertensive rats (SHR) and normotensive controls (Wistar Kyoto, WKY) at 5-7 and 15-17 weeks of age were compared. Systolic blood pressures were not different at 5-7 weeks but those of SHR were significantly elevated (177 +/- 4 mmHg) (1 mmHg = 133.322 Pa) at 15-17 weeks. Spontaneous activity, frequency, and tension were greater in SHR for both age groups. Young SHR were more sensitive to K+ at 5-7 weeks but less sensitive at 15-17 weeks than age-matched WKY rats. Sensitivity to Ca2+ in a K+-depolarizing medium was higher in SHR than in WKY for both age groups. Maximum tension responses to K+ or Ca2+ were greater in SHR. The Ca2+ channel antagonists nifedipine, nitrendipine, and nisoldipine were potent inhibitors of both noradrenaline- and K+-induced responses but did not show differences in inhibitory activity between WKY and SHR.
比较了5至7周龄和15至17周龄的自发性高血压大鼠（SHR）和血压正常对照大鼠（Wistar Kyoto，WKY）门静脉的反应性。5至7周龄时收缩压无差异，但15至17周龄时SHR的收缩压显著升高（177±4 mmHg）（1 mmHg = 133.322 Pa）。两个年龄组的SHR的自发活动、频率和张力均更高。5至7周龄的年轻SHR对钾离子更敏感，但在15至17周龄时比年龄匹配的WKY大鼠更不敏感。在两个年龄组中，SHR在钾离子去极化介质中对钙离子的敏感性均高于WKY。SHR对钾离子或钙离子的最大张力反应更大。钙离子通道拮抗剂硝苯地平、尼群地平和尼索地平是去甲肾上腺素和钾离子诱导反应的有效抑制剂，但在WKY和SHR之间未显示出抑制活性的差异。
