Sironi M, Canegrati M A, Romano M, Vecchi A, Spreafico F
Cancer Treat Rep. 1984 Apr;68(4):643-5.
A model, employing murine L1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.
利用一种模型来探索联合免疫毒素 - 化学疗法治疗的体内治疗潜力，该模型采用在体外结合了人工决定簇TNP的小鼠L1210白血病细胞以及抗DNP抗体 - 蓖麻毒素A链缀合物。在免疫毒素和化学疗法作为单一疗法仅具有微弱治疗活性的条件下，它们的联合使用却具有显著疗效。
