Fetal mortality in oral cleft families (VII): Birth intervals.

Birth intervals in sibships of oral cleft probands are analysed to detect prolonged delays between successive pregnancies. Such intervals are useful indicators of undetected fetal mortality. The present study indicates that the average interval for 462 cleft families in Indiana is 30.61 months. The average interval leading to the birth of a cleft child is 33.94 and is significantly greater than the average interval for the entire sample. Although the contraception status of the Indiana population is not known, the significantly greater delay preceding the birth of a cleft child is indicative of a cause other than contraception. This finding is in agreement with the report by Drillien et al. (1966) that abnormal conceptions occur more frequently adjacent to cleft offspring. It is interesting that some increase in the average interval is also noted in the present study immediately following the birth of a cleft child. Such delays occurring both preceding and following the birth of a cleft child (in contrast to smaller intervals for other pregnancies in the same sibships) may indicate excessive fetal wastage due to a combination of genetic and environmental factors.