来自吸毒成瘾孕妇及其新生儿的染色体畸变
Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
作者信息
Amarose A P
出版信息
J Reprod Med. 1978 Jun;20(6):323-8.
PMID:671412
Abstract
Cytogenetic data were obtained prenatally and at delivery from 99 addicted pregnant women (80 from a methadone maintenance program and 19 heroin addicts) and their 101 offspring at delivery. About 10% of the 27,907 cells scored showed chromosomal aberrations. Chromosome damage was random and affected all chromosomes. There were no standard abnormal karyotypes. Apgar scores appeared to have some type of association with chromosome damage. In this study there were about 14 aberrations for every 10 aberrant cells scored.
摘要
对99名成瘾孕妇（80名来自美沙酮维持治疗项目，19名海洛因成瘾者）及其101名分娩时的后代进行了产前和分娩时的细胞遗传学数据采集。在27907个计分细胞中，约10%显示出染色体畸变。染色体损伤是随机的，影响所有染色体。没有标准的异常核型。阿氏评分似乎与染色体损伤存在某种关联。在本研究中，每10个计分的异常细胞约有14个畸变。
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