去氧肾上腺素和可乐定对大鼠尾动脉86Rb外流及收缩的不同作用。
Different effects of phenylephrine and clonidine on 86Rb efflux and on contraction in the rat caudal artery.
作者信息
Desaulles E, Heitz C, Tetsi L, Stoclet J C
出版信息
Eur J Pharmacol. 1984 Feb 10;98(1):141-4. doi: 10.1016/0014-2999(84)90121-3.
A large transitory efflux of 86Rb was induced by concentrations of phenylephrine (10(-6) and 10(-4)M) or clonidine (10(-4)M) which were able to produce phasic contraction. By contrast, a lower concentration of clonidine (10(-6) M), which could only induce a slower (tonic) contraction, only produced a weak but sustained 86Rb efflux. These results show qualitative and quantitative differences in the effects of the two alpha-agonists. They further support the view that phasic and tonic alpha-adrenergic responses may be related to different mechanisms.
苯肾上腺素（10⁻⁶和10⁻⁴M）或可乐定（10⁻⁴M）的浓度可诱导86Rb的大量短暂外流，这些浓度能够产生阶段性收缩。相比之下，较低浓度的可乐定（10⁻⁶M）只能诱导较慢的（紧张性）收缩，仅产生微弱但持续的86Rb外流。这些结果显示了两种α激动剂作用的质和量的差异。它们进一步支持了阶段性和紧张性α肾上腺素能反应可能与不同机制相关的观点。
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