Sherwin I
Exp Neurol. 1984 May;84(2):463-77. doi: 10.1016/0014-4886(84)90242-5.
Single-unit activity occurring during seizures and interictal periods was studied in primary (penicillin) and secondary (mirror) neocortical epileptogenic foci in the rat. The results revealed that significant differences exist between the behavior of primary and dependent secondary focus neurons. The most prominent difference appeared to be the marked tendency for suppression of neuronal firing in secondary focus units, which was evident both interictally and during seizures. Moreover, seizures did not appear to be more potent than interictal discharges alone, in shifting the firing patterns of secondary focus neurons toward that displayed by primary focus neurons. These data have relevance for current theories regarding the induction of independent (chronic) secondary epileptogenic foci.
在大鼠的原发性（青霉素诱发）和继发性（镜像）新皮质癫痫病灶中，研究了癫痫发作期和发作间期出现的单神经元活动。结果显示，原发性病灶神经元和从属继发性病灶神经元的行为存在显著差异。最显著的差异似乎是继发性病灶单位神经元放电受到抑制的明显倾向，这在发作间期和癫痫发作期间均很明显。此外，在将继发性病灶神经元的放电模式转变为原发性病灶神经元所表现出的放电模式方面，癫痫发作似乎并不比单独的发作间期放电更有效。这些数据与当前关于独立（慢性）继发性癫痫病灶诱发机制的理论相关。
