Fornůsek L, Vĕtvicka V
Folia Biol (Praha). 1984;30(1):67-79.
We studied phagocytic activity of murine macrophages for 2-hydroxyethylmethacrylate particles, determined the percentage of cells carrying Fc receptors for IgG1, IgG2A, IgG2B, IgM, IgA and IgE, and phagocytic activity mediated by Fc receptors, as well as pinocytic activity and adherence of normal and thioglycollate- or proteose peptone-stimulated peritoneal macrophages. A significant increase in phagocytic activity was found (the exceptions were FcR for IgG2A, IgG2B and IgM in TG-stimulated and FcR for IgA in PP-stimulated macrophages). Pinocytic activity increased two- to three-fold, adherence capacity, on the contrary, fell to one third in the TG-stimulated macrophages, whereas it remained unchanged after treatment in the PP-stimulated ones. Further evidence is provided for considerable differences in the properties of normal and stimulated peritoneal macrophages.
我们研究了小鼠巨噬细胞对甲基丙烯酸2-羟乙酯颗粒的吞噬活性，测定了携带针对IgG1、IgG2A、IgG2B、IgM、IgA和IgE的Fc受体的细胞百分比，以及由Fc受体介导的吞噬活性，还有正常及经巯基乙酸盐或蛋白胨刺激的腹腔巨噬细胞的胞饮活性和黏附性。发现吞噬活性有显著增加（例外情况是经巯基乙酸盐刺激的巨噬细胞中针对IgG2A、IgG2B和IgM的FcR，以及经蛋白胨刺激的巨噬细胞中针对IgA的FcR）。胞饮活性增加了两到三倍，相反，黏附能力在经巯基乙酸盐刺激的巨噬细胞中降至三分之一，而在经蛋白胨刺激的巨噬细胞中处理后保持不变。这进一步证明了正常和刺激后的腹腔巨噬细胞在特性上存在相当大的差异。
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