Walsh D A, Sancilio L F, Reese D L
J Med Chem. 1978 Jun;21(6):582-5. doi: 10.1021/jm00204a015.
A series of 1-benzoyl- and 1-phenylisoquinolineacetic acid derivatives was prepared and tested for antiinflammatory activity. The most potent compound synthesized, 1-(4-chlorophenyl)-3-isoquinolineacetamide, was as active as phenylbutazone in the Evans blue carrageenan-induced pleural effusion assay but inactive in the adjuvant-induced arthritis model of chronic inflammation.
制备了一系列1-苯甲酰基-和1-苯基异喹啉乙酸衍生物，并对其抗炎活性进行了测试。合成的最有效化合物1-(4-氯苯基)-3-异喹啉乙酰胺，在伊文思蓝角叉菜胶诱导的胸腔积液试验中与保泰松活性相当，但在佐剂诱导的慢性炎症关节炎模型中无活性。
