Hodnett E M, Amirmoazzami J, Tien Hai Tai J
J Med Chem. 1978 Jul;21(7):652-7. doi: 10.1021/jm00205a012.
Eleven new polymeric carboxylic acids with widely different solubilities in water have been synthesized. The activities of these polymers against the ascitic sarcoma 180 tumor of mice and their acute toxicities in mice have been compared with molecular parameters of the polymers such as molecular weights, charge densities, and abilities to complex calcium and magnesium ions. The maximum effectiveness of these polymers against ascitic sarcoma 180 of mice is greatest for those polymers having fewer carboxyl groups ionized at pH 7. Toxicities are lower for polymers having more carboxyl groups ionized at pH 7.
已合成了11种在水中溶解度差异很大的新型聚合羧酸。将这些聚合物对小鼠腹水肉瘤180肿瘤的活性及其在小鼠中的急性毒性与聚合物的分子参数（如分子量、电荷密度以及络合钙和镁离子的能力）进行了比较。这些聚合物对小鼠腹水肉瘤180的最大有效性对于那些在pH 7时电离的羧基较少的聚合物而言是最大的。对于在pH 7时电离的羧基较多的聚合物，其毒性较低。
