[马吲哚对大鼠脑内游离脂肪酸代谢的影响]

[Effect of mazindol on free fatty acid metabolism in the brain of rats].

作者信息

Mizobuchi M, Matsuoka N, Saito Y, Yoshida S, Kumagai A

出版信息

Nihon Yakurigaku Zasshi. 1984 Jan;83(1):33-7.

Abstract

The effects of mazindol which is known as a anorexigenic agent on the free fatty acid metabolism in the brain were studied. One-half mg of mazindol was orally administered to rats weighing 500 g for 5 days. Body weight was reduced by 10%, compared to the control. Serum levels of free fatty acid, triglyceride, total cholesterol and phospholipid were decreased. The effect of mazindol on the incorporation of [1-14C] palmitic acid into various lipids in the brain were studied. When mazindol (5 mg) was administered one hr before injection of [1-14C] palmitic acid to the internal carotid artery of rats ad libitum, incorporation of [1-14C] palmitic acid into free fatty acids in the cerebrum and diencephalon was lower than that of the control, but incorporation into phospholipid and triglyceride were higher than that of the control. When mazindol was injected into fasting rats, incorporation into free fatty acid in cerebrum and diencephalon was increased compared with the control, and the incorporations into phospholipid and triglyceride were decreased.

摘要

研究了作为一种食欲抑制剂的马吲哚对大脑中游离脂肪酸代谢的影响。给体重500克的大鼠口服0.5毫克马吲哚，持续5天。与对照组相比，体重减轻了10%。血清游离脂肪酸、甘油三酯、总胆固醇和磷脂水平降低。研究了马吲哚对[1-14C]棕榈酸掺入大脑各种脂质的影响。当在给自由进食的大鼠颈内动脉注射[1-14C]棕榈酸前1小时给予马吲哚（5毫克）时，[1-14C]棕榈酸掺入大脑和间脑中游离脂肪酸的量低于对照组，但掺入磷脂和甘油三酯的量高于对照组。当给禁食大鼠注射马吲哚时，与对照组相比，大脑和间脑中游离脂肪酸的掺入量增加，而磷脂和甘油三酯的掺入量减少。