Weisweiler P, Heinemann V, Schwandt P
Int J Clin Pharmacol Ther Toxicol. 1984 Apr;22(4):204-6.
We studied the effect on the serum LCAT activity and apolipoproteins in ten subjects with primary hypercholesterolemia after treatment with beta-sitosterol. The 2-month administration of beta-sitosterol resulted in an increase of the fractional as well as of the molar esterification rate of the LCAT. These alterations were associated with a decrease of the levels of total, esterified, and unesterified cholesterol, whereas the levels of HDL-cholesterol and the apolipoproteins A-I and B were not affected. We conclude that beta-sitosterol primarily lowers cholesterol-rich lipoproteins with a lower density range than LDL via an accelerated esterification rate of the LCAT enzyme.
我们研究了β-谷甾醇治疗对十名原发性高胆固醇血症患者血清卵磷脂胆固醇酰基转移酶（LCAT）活性和载脂蛋白的影响。给予β-谷甾醇2个月导致LCAT的分数酯化率和摩尔酯化率均增加。这些改变与总胆固醇、酯化胆固醇和未酯化胆固醇水平的降低相关，而高密度脂蛋白胆固醇、载脂蛋白A-I和载脂蛋白B的水平未受影响。我们得出结论，β-谷甾醇主要通过加速LCAT酶的酯化率来降低密度范围低于低密度脂蛋白（LDL）的富含胆固醇的脂蛋白。
