Glass A R, Anderson J, Herbert D, Vigersky R A
J Androl. 1984 Mar-Apr;5(2):99-102. doi: 10.1002/j.1939-4640.1984.tb00782.x.
In previous studies, male rats fed a low-protein diet beginning at weaning were found to have impaired sexual development through age 11 weeks when compared to food-restricted, weight-matched controls fed a diet with normal protein content. To determine whether male rats show long-term adaptation of the reproductive axis to low-protein feeding, we assessed sexual maturation and growth in rats fed a low protein (9%) diet from weaning until sacrifice at various points in time between ages 79 and 185 days. After age 80 days, there was no difference in reproductive organ weights (prostate, seminal vesicles, testis) or serum hormone levels (luteinizing hormone, follicle stimulating hormone, testosterone) between protein-deficient animals and food-restricted weight-matched controls given a normal diet. In addition, there was no difference between protein-deficient animals and controls in indices of linear growth (naso-anal and tail length) or fatness (Lee index). We conclude that both growth and reproductive function of male rats show adaptation to long term feeding of a low-protein diet.
在先前的研究中，发现从断奶开始就喂食低蛋白饮食的雄性大鼠，与喂食正常蛋白质含量饮食的食物限制、体重匹配的对照组相比，到11周龄时其性发育受损。为了确定雄性大鼠的生殖轴是否对低蛋白喂养表现出长期适应性，我们评估了从断奶到79至185天之间不同时间点处死的喂食低蛋白（9%）饮食的大鼠的性成熟和生长情况。80日龄后，蛋白质缺乏动物与喂食正常饮食的食物限制体重匹配对照组之间的生殖器官重量（前列腺、精囊、睾丸）或血清激素水平（促黄体生成素、促卵泡生成素、睾酮）没有差异。此外，蛋白质缺乏动物与对照组在线性生长指标（鼻肛长度和尾长）或肥胖指标（李氏指数）方面也没有差异。我们得出结论，雄性大鼠的生长和生殖功能均表现出对长期低蛋白饮食喂养的适应性。
