Das Gupta V, Stewart K R
J Clin Hosp Pharm. 1984 Mar;9(1):21-7. doi: 10.1111/j.1365-2710.1984.tb00915.x.
The stability of cefsulodin in aqueous solutions of various pH values, buffer concentrations, ionic strengths and intravenous admixtures were studied using a stability-indicating high-pressure liquid chromatography method. The pH range of optimum stability was determined to be 3.2-5.7. Cefsulodin was more stable on the acidic and less on the alkaline side as compared with most of the other cephalosporins such as cefoxitin (pH range of optimum stability approximately 4-7). In 5% dextrose and 0.9% sodium chloride injection, cefsulodin was stable (at least 90% potent) for about 1, 17 and at least 60 days at 24 degrees, 5 degrees and -10 degrees C, respectively.
采用一种稳定性指示高压液相色谱法，研究了头孢磺啶在不同pH值、缓冲液浓度、离子强度的水溶液及静脉内混合液中的稳定性。确定最佳稳定性的pH范围为3.2 - 5.7。与大多数其他头孢菌素如头孢西丁（最佳稳定性的pH范围约为4 - 7）相比，头孢磺啶在酸性条件下更稳定，在碱性条件下稳定性较差。在5%葡萄糖注射液和0.9%氯化钠注射液中，头孢磺啶在24℃、5℃和 - 10℃下分别稳定（效力至少为90%）约1天、17天和至少60天。
