Visser C M, Kellogg R M
J Mol Evol. 1978 Jun 20;11(2):163-8. doi: 10.1007/BF01733891.
A challenging theme in bioorganic chemistry is the unification of established theories of biochemistry and organic chemistry to provide new patterns for interpretation and experimentation. Especially relevant examples of such interactions can be drawn from the field of enzyme catalysis and, in particular, the role of cofactors therein. Knowledge of the chemical mechanisms by which some of the cofactors function has progressed rapidly with the aid of studies of the cofactors themselves (or compounds of related structure, "models") stripped of the accompanying apoenzyme. The striking successes in this field likely arise from a fundamental resemblance between bioorganic chemistry (especially coenzyme models) and chemical evolution before the appearance of coded polypeptide enzymes.
生物有机化学中一个具有挑战性的主题是将既定的生物化学理论与有机化学理论统一起来，以提供新的解释和实验模式。这种相互作用的特别相关的例子可以从酶催化领域中找到，特别是辅因子在其中的作用。借助对去除了伴随的脱辅酶的辅因子本身（或相关结构的化合物，“模型”）的研究，一些辅因子发挥作用的化学机制的知识得到了迅速发展。该领域取得的显著成功可能源于生物有机化学（尤其是辅酶模型）与编码多肽酶出现之前的化学进化之间的基本相似性。
