Kontula K, Mustajoki P, Paetau A, Pelkonen R
J Endocrinol Invest. 1984 Feb;7(1):35-40. doi: 10.1007/BF03348373.
A young woman developed clinical features of anorexia nervosa with a maximal loss of ideal body weight of 54 per cent at the age of 16 yr. A partial recovery from the anorectic symptoms was encountered six years later. At the age of 27 yr pituitary Cushing's disease was diagnosed and corticotroph cell pituitary adenoma subsequently removed by transsphenoidal surgery. Within two years after the operation the clinical and biochemical signs of hypercortisolism had disappeared but some of the anorectic features reappeared. Without neglecting the likelihood of a simple coincidence, the possibility of a common pathogenetic mechanism for anorexia nervosa and Cushing's disease, either affecting the function of the hypothalamic serotonergic pathways or concentration of glucocorticoid receptors, is discussed.
一名年轻女性出现神经性厌食症的临床症状，16岁时理想体重最大降幅达54%。六年后厌食症状部分缓解。27岁时被诊断为垂体库欣病，随后经蝶窦手术切除促肾上腺皮质激素细胞垂体腺瘤。术后两年内，高皮质醇血症的临床和生化体征消失，但一些厌食特征再次出现。在不忽视单纯巧合可能性的情况下，本文讨论了神经性厌食症和库欣病存在共同发病机制的可能性，该机制可能影响下丘脑5-羟色胺能通路功能或糖皮质激素受体浓度。
