Litvinov N N, Voronin V M
J Hyg Epidemiol Microbiol Immunol. 1984;28(1):5-9.
The evident growth of tumour morbidity makes analysis of the fundamental problems of neoplasm prophylaxis in man particularly urgent. The establishment of maximum permissible concentrations for carcinogenic agents calls for further exploration into the problem of threshold action of carcinogens and elaboration of a methodology for quantitative assessment of the biological effects of certain environmental factors. In particular, the available data on the ability of low-intensity environmental factors to modify the organism's general resistance and thereby produce in it conditions for materialization of the untoward effects of carcinogens invite further work in this direction. The study of environmental factors as possible modifiers of blastomatosis and investigation of the modification mechanisms involved are an immediate and topical task. Quantitative analysis of these modifying effects would allow establishment of well-grounded hygienic norms as the next step. Thus, study of the regularities involved, development of a fundamental methodology and accumulation of facts on the influence of low-intensity environmental factors on carcinogenesis and the cancer effect should be helpful in devising scientifically based measures of lowering the growth of tumour morbidity.
肿瘤发病率的明显上升使得对人类肿瘤预防基本问题的分析变得尤为迫切。确定致癌物的最大允许浓度需要进一步探讨致癌物的阈值作用问题，并制定一种定量评估某些环境因素生物学效应的方法。特别是，关于低强度环境因素改变机体一般抵抗力从而为致癌物不良效应的显现创造条件的现有数据，促使在这一方向上开展进一步研究。将环境因素作为可能的母细胞瘤修饰因子进行研究，并探究其中的修饰机制，是一项紧迫且热门的任务。对这些修饰效应进行定量分析将有助于下一步确立有充分依据的卫生规范。因此，研究其中的规律、开发基本方法以及积累关于低强度环境因素对致癌作用和癌症效应影响的数据，应有助于制定基于科学的降低肿瘤发病率增长的措施。
