亚甲基柠檬酸的二阿司匹林
Diaspirins of methylenecitric acid.
作者信息
Massil S E, Shi G Y, Klotz I M
出版信息
J Pharm Sci. 1984 Mar;73(3):418-20. doi: 10.1002/jps.2600730338.
PMID:6716258
Abstract
A series of bissalicylic esters of methylenecitric acid have been prepared and, as a probe of their potential as antisickling agents, tested for their ability to modify hemoglobin. Substantial acylation of hemoglobin was obtained with these dicarboxylate esters at 1-5 mM concentrations.
摘要
已制备了一系列亚甲基柠檬酸的双水杨酸酯，并作为抗镰状化剂潜力的探针，测试了它们修饰血红蛋白的能力。在1-5 mM浓度下，这些二羧酸酯可使血红蛋白发生大量酰化。
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