[冠心病不同阶段的免疫变化]

[Immunologic shifts at different stages of coronary disease].

作者信息

Kitaev M I, Dvorkin M I

出版信息

Kardiologiia. 1984 Feb;24(2):86-9.

Abstract

Immunologic shifts and indices of nonspecific reactivity were examined in 261 coronary heart disease patients (40 patients with angina pectoris, 137 with acute myocardial infarction and 124 patients with postinfarctional cardiosclerosis). Cell-mediated and humoral immune responses to the infarctional antigen affecting the prognosis and the clinical course of the disease were determined in the acute, subacute and long-term periods of coronary pathology. Autoimmune reactions to the myocardial innate antigen can be detected at all stages of coronary heart disease. Myocardial infarction is also characterized by dysfunctions of individual links of nonspecific reactivity.

摘要

对261例冠心病患者（40例心绞痛患者、137例急性心肌梗死患者和124例心肌梗死后心硬化患者）的免疫变化和非特异性反应指标进行了检查。在冠心病的急性期、亚急性期和长期阶段，测定了针对影响疾病预后和临床病程的梗死抗原的细胞介导免疫反应和体液免疫反应。在冠心病的各个阶段都能检测到对心肌自身抗原的自身免疫反应。心肌梗死的特征还在于非特异性反应个别环节的功能障碍。

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