Griffin D S, Baselt R C
J Anal Toxicol. 1984 Mar-Apr;8(2):97-9. doi: 10.1093/jat/8.2.97.
Gas-liquid chromatography with nitrogen-phosphorus detection was used to analyze blood and urine from a volunteer who ingested 50 mg of cyclizine hydrochloride. A peak blood cyclizine concentration of 69 ng/mL was observed 2 hr after drug administration, and the levels declined thereafter in a biphasic manner, with estimated half-lives of 7 and 24 hr for the early and late phases, respectively. The peak urine cyclizine concentration of 12.5 ng/mL was achieved at 4 hr after administration; only 0.01% of the dose was excreted in the 24 hr urine. Norcyclizine was not observed in blood or urine; however, the detectability of the method for this metabolite is poor relative to the parent drug.
采用带氮磷检测的气相色谱法对一名摄入50毫克盐酸赛克利嗪的志愿者的血液和尿液进行分析。给药后2小时观察到血液中赛克利嗪的峰值浓度为69纳克/毫升，此后浓度呈双相下降，早期和晚期的估计半衰期分别为7小时和24小时。给药后4小时尿液中赛克利嗪的峰值浓度达到12.5纳克/毫升；24小时尿液中仅排出0.01%的剂量。血液或尿液中未检测到去甲赛克利嗪；然而，该方法对这种代谢物的检测能力相对于母体药物较差。
