Nilsson P, Johansson S G, Danielson B G
Nephron. 1984;37(1):25-9. doi: 10.1159/000183202.
The magnesium status of 22 hemodialysis patients was studied by analyses of serum, skeletal muscle and peripheral blood lymphocyte levels of magnesium. Despite elevated serum magnesium, normal magnesium levels were noted in skeletal muscle and lymphocytes. 12 patients were exposed to a low dialysate magnesium concentration, resulting in normalization of serum magnesium but no changes in muscle or lymphocyte magnesium, which might indicate slow exchange between these intracellular stores and the extracellular fluid. Normalization of serum magnesium was followed by a slight rise in circulating parathyroid hormone levels without noticeable changes in serum calcium or phosphate levels. Since signs of an absolute magnesium excess were not detected, a combination of low dialysate magnesium and the use of an oral magnesium compound as a phosphate binder might be a way to decrease aluminium exposition in hemodialysis patients.
通过分析22例血液透析患者的血清、骨骼肌和外周血淋巴细胞中的镁水平，对其镁状态进行了研究。尽管血清镁升高，但骨骼肌和淋巴细胞中的镁水平正常。12例患者暴露于低透析液镁浓度下，血清镁恢复正常，但肌肉或淋巴细胞中的镁无变化，这可能表明这些细胞内储存与细胞外液之间的交换缓慢。血清镁恢复正常后，循环甲状旁腺激素水平略有升高，而血清钙或磷水平无明显变化。由于未检测到绝对镁过量的迹象，低透析液镁与使用口服镁化合物作为磷结合剂相结合可能是减少血液透析患者铝暴露的一种方法。
