Responses of medullary reticulospinal neurons to sinusoidal rotation of neck in the decerebrate cat.

The electrical activity of 132 neurons located in the inhibitory area of the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis and ventralis has been recorded in precollicular decerebrate cats during sinusoidal displacement of the neck. This was achieved by rotation of the body about the longitudinal axis of the animal, while maintaining the head stationary. In particular, 85 neurons were activated antidromically by stimulation of the spinal cord at T12 and L1, the remaining 47 units were not activated antidromically. Among these reticular neurons tested, 66 out of 85 (i.e. 77.6%) of the neurons that were, and 31 out of 47 (i.e. 66.0%) of the neurons that were not antidromically activated responded to slow neck rotation at the frequency of 0.026 Hz and at the peak amplitude of displacement of 10 degrees. The units influenced by neck rotation showed a periodic modulation of the firing rate in response to sinusoidal stimulation of neck receptors. In particular, 70 of 97 units (i.e. 72.2%) were excited during side-down neck rotation and depressed during side-up rotation, while 19 of 97 units (i.e. 19.6%) showed the opposite pattern. In both instances, the peak of the responses occurred with an average phase lead of +41 degrees for the extreme side-up or side-down neck displacement. The remaining 8 units (i.e. 8.2%) showed a prominent phase shift of the peak of their response relative to neck position. The proportion of units excited during side-down neck rotation were almost equally distributed throughout the whole rostro-caudal extent of the reticular structures explored. Responses to neck rotation were detectable at 0.25 degrees of peak displacement. The gain (imp./s/deg.) and the sensitivity (%/deg., i.e. percentage change of the mean firing rate per degree of displacement) in responses of reticulospinal neurons decreased by increasing the peak amplitude of neck rotation from 1 to 10 degrees at a frequency of 0.026 Hz. Therefore, the system did not behave linearly with respect to amplitude of stimulation. By increasing the frequency of stimulation from 0.008 to 0.32 Hz at the fixed amplitude of 10 degrees, the gain, sensitivity and phase lead of responses increased for frequencies of neck rotation above 0.051 Hz. Reticulospinal neurons may thus monitor changes in neck position as well as in velocity of neck rotation. Responses of reticulospinal neurons to neck rotation are discussed in relation to the responses to the same stimulus recently described of vestibulospinal neurons originating from the lateral vestibular nucleus.(ABSTRACT TRUNCATED AT 400 WORDS)