Beuerman R W, Rózsa A J
Neurosci Lett. 1984 Jan 27;44(1):99-104. doi: 10.1016/0304-3940(84)90228-3.
Following various types of wounds and subsequent denervation, the reinnervation of the rabbit corneal epithelium was found to occur in two distinct phases that overlapped in time. In the first phase large numbers of collateral sprouts originated from the unmyelinated plexus at various distances proximal to the site of transection. Light and electron microscopic observations revealed that the sprouts began to degenerate about 7 days after wounding. Collateral sprouts were replaced by an equally numerous population of regenerating neurites extending from the transected stumps of the pre-terminal axons. We conclude that, in the wounded cornea, normal neurology is reconstituted by regenerating neurites, and not by collateral sprouts, which proliferate and then degenerate early in the healing process.
在经历各种类型的创伤以及随后的去神经支配后，发现兔角膜上皮的再神经支配过程呈现出两个不同阶段，这两个阶段在时间上相互重叠。在第一阶段，大量的侧支芽从离横断部位不同距离的无髓神经丛发出。光镜和电镜观察显示，这些芽在受伤约7天后开始退化。侧支芽被同样数量的从终末前轴突横断残端延伸而来的再生神经突所取代。我们得出结论，在受伤的角膜中，正常的神经功能是由再生神经突重建的，而不是由侧支芽重建的，侧支芽在愈合过程早期增殖然后退化。
