Maebashi M, Yoshinaga K
Tohoku J Exp Med. 1984 Feb;142(2):173-82. doi: 10.1620/tjem.142.173.
A vasoactive substance was produced in serum when incubated at 37 degrees C. This substance differed from other known vasoactive agents. It was a phospholipid and caused an elevation in blood pressure by its direct vasoconstriction. This pressor substance increased in the incubated sera of patients with essential hypertension and in spontaneously hypertensive rats. But it was significantly low in humans and dogs in anephric states. These results suggest that the pressor substance participates in the pressor mechanism of essential hypertension and its production is closely related to the kidney.
当在37摄氏度孵育时，血清中会产生一种血管活性物质。这种物质与其他已知的血管活性因子不同。它是一种磷脂，通过直接血管收缩导致血压升高。这种升压物质在原发性高血压患者和自发性高血压大鼠的孵育血清中增加。但在无肾状态的人和狗中显著降低。这些结果表明，这种升压物质参与原发性高血压的升压机制，其产生与肾脏密切相关。
